Automated Cell Counters
Count Cells Without Slides™
Accurate Across the Widest Range of Cell Size and Density
Easy to Learn. Powerful to Use.
21 CFR Part 11 Compliance Ready
Optimized Measurement Apps
DeNovix CellDrop Series instruments are stand-alone systems equipped with intuitive, easy-to-use apps for automatic cell counting and viability analysis.
Fast count of Brightfield cell image
Live/dead assessment using Trypan Blue assay
Cells/mL, cell size and % viability reported
Cell viability analysis using acridine orange (AO) and propidium iodide (PI)
Analyze primary cells in the presence of debris AO for identification of nucleated cells PI for cell viability AO/PI for live/dead
GFP Transfection Efficiency
SIX formats intuitive results analysis formats
Cell Size Gating
Cell Size Histograms allow easy gating for non-target cells or cell debris. Simply drag the slider to set the cell size of interest and view the results in real time. Results are instantly re-calculated excluding all debris or cells that fall outside of the defined size range
GFP Intensity Gating
When using the dedicated GFP Count App, users can gate cells by fluorescence intensity as well as size. The intensity histogram displays the number of cells counted at each GFP intensity level allowing the exclusion of non-GFP expressing cells or low expressing cells to be excluded from analysis.
Advanced Declustering Algorithms
Ideally, samples will contain only single cells, but clusters are commonplace with some cell types or at higher cell density. All EasyApps Count Apps use proprietary declustering algorithms developed by DeNovix. Complex samples of regular or irregular cells over a wide range of cell density can be rapidly and accurately analyzed using CellDrop.
Analysis of cluster size and frequency can be performed and graphically displayed.
Primary Cell Counting
Primary cell samples are challenging to quantify for traditional cell counting methods. EasyApps makes the analysis simple and accurate with two optimzed Count Apps for fluorescence and brightfield measurement of primary cell samples.
Using the dual fluorescence capabilities of the CellDrop FL, debris and anucleate cells are excluded from analysis while viability of the nucleated cells is analyzed.
EasyApps automatically calculates a wide range of application-specific metrics for each cell sample. Data is clearly displayed on-screen and auto-saved to a large onboard hard drive. Metrics include:
Total / Live / Dead Cell Count
Total / Live / Dead Cell Per mL
Define a target cell number or density and culture volume and the dilution calculator will automatically calculate dilution volumes of cell culture and buffer based on each cell count. Dilution guidance is displayed prominently on-screen and printed reports for convenient sample processing.
Graphical Data Display
A wide range of graph types are available to gain additional sample insight. Overlay multiple samples from the same session or from the data archive for powerful data visualization.
Total / Live / Dead Cell Count
Live and Dead Cells (by size)
% GFP Transfection Efficiency
Simply and securely connect CellDrop to your network by Wifi or Ethernet to enable data exporting by email, or print reports to network or label printers. Each measurement is automatically saved to a large onboard memory enabling storage and retrieval of thousands of samples.
|Dynamic Range||7 x 102 – 2.5 x 107 cells/ml|
|Cell Size Range||4 – 400 µm|
|Sample Volume||5.0 µL @50 µm chamber height|
10 µL @100 µm chamber height (standard)
40 µL @400 µm chamber height
|Measurement Speed||Brightfield- 3 seconds @1 x 106 cell/mL|
Dual Fluorescence- 8.5 seconds @1 x 106 cell/mL
|Optical Modes||CellDrop FL – Dual Fluorescence, Single Fluorescence, Brightfield, Fluorescence + Brightfield|
CellDrop BF – Brightfield only
|Sample Surfaces||Optical Sapphire|
|Brightfield Illumination||LED 530 nm|
|Fluorescence Illumination||LED 470 nm|
|Emission Filters||530 nm +/- 25 nm|
645nm +/- 37 nm
|Gesture Recognition||Multipoint touch, swipe, pinch|
|Display||7” high definition color display|
|Glove Compatibility||All common laboratory gloves|
|Camera||CellDrop FL – Basler acA2040-55µm|
CellDrop BF – Basler daA2500- 14µm
|Images||2048 x 800 px (3.15 MB) with overlay capabilities|
|Focus||User-controlled onscreen coarse and fine adjustment|
|Detector||CellDrop FL – Sony IMX265|
CellDrop BF – ON Semiconductor MT9P031
|Connectivity||WiFi, Ethernet, HDMi, USB|
|Footprint (LxWxH)||37 x 21 x 18 cm|
|Operating Voltage||12 VDC|
|Approvals||UL/CSA, CE, FCC, Japan CAB|
|Internal Storage||120 GB solid state drive – upgradable to 1 TB|
|Accessories||Barcode reader, keyboard, mouse, 20 µL pipette|
|Patents||US 10,302,568 and 10,598,598|
|CellDrop FL- UNLTD||2 Channel Fluorescence Cell Counter with Unlimited Counts||-||DeNovix|
|CellDrop FL- PAYG||2 Channel Fluorescence Cell Counter- Pay-As-You-Go||-||DeNovix|
|CellDrop BF- UNLTD||Bright Field Cell Counter with Unlimited Counts||-||DeNovix|
|CellDrop BF- PAYG||BrightField Cell Counter- Pay-As-You-Go||-||DeNovix|